We are interested in gene-environment interactions, with a particular focus on the molecular mechanisms linking chronic stimulation of stress responsive pathways to changes in genome function at the transcriptional and post-transcriptional level. We aim to elucidate how chromatin and post-transcriptional RNA modifications are involved in mediating the influence of environmental exposures on ageing- and metabolic-related disease.

 

To this end, we utilise profiles established using a range of genome-wide profiling techniques to identify novel regulatory pathways and then determine the consequences of altering these for cell function.  Our goal is to elucidate how such mechanisms contribute to human disease and phenotypic diversity that cannot be accounted for purely by the underlying genetic variation.